Dense-deposit disease is a complement-mediated disorder characterized by a proliferative glomerulonephritis, bright capillary-wall C3 staining on immunofluorescence microscopy, and large ...

Obesity, insulin resistance and diabetes are associated with raised plasma concentrations of C3 and C4. 16, 17, 18, 19 Several links of evidence suggest that C3 also ...

Atypical hemolytic–uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion may transiently maintain normal levels ...

Hereditary angioedema (HAE) is diagnosed through blood tests that measure complement protein (C4) and complement inhibitor (C1-INH) levels. Low C4 levels strongly suggest HAE, especially during an ...

Immunotherapy is increasingly becoming standard therapy in cancer, with technology, such as checkpoint inhibitors and cell therapy, raising the efficacy bar in many forms of the disease. But the ...