The cell cycle is governed by a network of surveillance mechanisms that detect DNA lesions and coordinate repair with progression through G1, S, G2 and M phases. Central to this system are sensor ...

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages ...

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Checkpoint inhibitors are antibody-based cancer therapies that unlock the immune system’s natural ability to fight cancer. These treatments work by blocking special proteins called immune checkpoints, ...

When many cancers advance, spread and reoccur, checkpoint inhibitors can help keep difficult tumors at bay. These antibody-based immunotherapies can restore the body’s ability to recognize and ...

The interplay between immune responses and cell death pathways is a central theme in immunology and pathology. Recent developments emphasize that these ...