When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...

Chemotherapy drugs are designed to shatter tumor DNA so thoroughly that cancer cells cannot survive. But one of the most ...

The data showed elevated levels of the metabolite αKG improved DNA repair, and blocking it made the cancer cells more sensitive to treatment.

Researchers found that cancer cells may repair chemotherapy-induced DNA damage, helping explain treatment resistance in ...

A new review highlights how human evolution has shaped the presence of pathogenic variations in DNA damage repair (DDR) genes, offering a new perspective on why modern populations face increased ...

Many cancers can be treated by administering DNA-damaging agents, such as platinum-based chemotherapy, because the resulting DNA damage causes the cancer cells to die. A subset of cancers, however, ...

Scientists have uncovered a surprising new trick used by one of cancer’s most notorious proteins. MYC, already infamous for ...

Key milestone positions ART6043 as the most advanced Pol-theta inhibitor in clinical development; the potentially first-in-class program is ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

RNA’s Surprising Role in DNA Repair New insights could lead to improved treatments for cancer and other diseases. Francesca Storici and her research team discovered a surprising role for RNA in DNA ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical ...

A new study suggests the APOE2 longevity gene may protect the brain from Alzheimer's by helping neurons repair DNA damage and ...