This article reviews designs of basket trials, discusses several issues that arise with their implementation, and examines the statistical criteria considered in the development of such trials. To ...

It also re-examines some of the conventional wisdom that previously dominated clinical trial design and discusses development and internal validation of a predictive biomarker as a new paradigm for ...

Literature reviews of cancer trials have highlighted the need for better understanding of phase II statistical designs. Understanding the key elements associated with phase II design and knowledge of ...