Base editing and prime editing can be used to permanently fix pathogenic variants but require the development of a distinct drug to correct each pathogenic variant. Suppressor transfer RNAs (sup-tRNAs ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Genetic medicine has made huge progress over the past two decades. Gene therapy, gene editing, and mRNA treatments are now approved for a growing number of conditions. These approaches focus on fixing ...