University of Chicago NewsOpinion

Are randomized controlled trials harming nonprofits?

In recent book, UChicago’s Nicole P. Marwell and Jennifer E. Mosley argue that the research method isn’t always the best tool ...
Medscape

Design Differences Likely Explain Mixed Results in Conduction System Pacing vs Biventricular Pacing Trials

Discordant results from two trials comparing conduction system pacing with biventricular pacing for cardiac resynchronization therapy (CRT) leave open the question of whether conduction system pacing ...
The New England Journal of Medicine

A Randomized Trial of Tenecteplase in Acute Central Retinal Artery Occlusion

We conducted a phase 3, double-blind, double-dummy, randomized, controlled trial involving adults with acute, nonarteritic central retinal artery occlusion who had symptom onset within 4.5 hours ...
The New England Journal of Medicine

Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases

Targeted indoor residual spraying focuses insecticide applications on common resting surfaces of Aedes aegypti mosquitoes (an arboviral disease vector) in houses, such as exposed lower sections of ...
ascopubs.org

Using Indirect Comparisons of Prospective, Randomized Trials to Make Therapeutic Decisions in Melanoma: Cross-Trial Comparisons as Surrogates for Proper Head-To-Head Studies?

Can We Offset Local Recurrence in Locally Advanced Non–Small Cell Lung Cancer? The Merry-Go-Round of Radiation Dose Escalation and Stubborn Outcomes First-Line Nivolumab Plus Relatlimab Versus ...
ascopubs.org

World-wide oligometastatic prostate cancer (omPC) meta-analysis leveraging individual patient data (IPD) from randomized trials (WOLVERINE): An analysis from the X-MET ...

A phase II trial of dostarlimab and niraparib combination therapy in patients with stage III-IV recurrent or refractory penile cancer. Association of baseline and on-treatment ctDNA fraction with ...