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What Actually Causes Sinusitis? Sinusitis occurs when the lining of the sinus cavities becomes inflamed and infected. These cavities are meant to be filled with air, but once drainage is blocked, mucus builds up and infection follows. One of the most common causes is a simple viral flu. Most viral infections resolve within a week, with or without treatment. However, certain viruses such as COVID-19, Influenza A and B, adenovirus, and RSV tend to linger longer and may trigger sinus inflammation.
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